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Scientists in Stockholm help explain how exercise and strength training helps block 'depression' brain chemicals

A New York Times articles explains how exercise scientifically helps to block the mind against depression, according to a new study involving mice, conducted at the Karolinska Institute in Stockholm. The findings conclude that anyone whose stress levels are high could benefit from strength training.

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The New York Times recently published a post on the positive effects of exercise on depression, which by now is common sense. The difference with this article is that after studies conducted by researchers at the Karolinska Institute in Stockholm, we now have a better understanding as to how the brain actually blocks chemicals that induce depressive thoughts.
The details of the study, which involved dozens of experiments on mice and their emotional feedback to various stress induced actions, can be found here: http://well.blogs.nytimes.com/2014/10/01/how-exercise-may-protect-against-depression.
It’s an interesting posts which delves into how scientists measure depression in mice and the effects exercise has on combatting depressive thoughts faced by the little critters.
The main takeaway from the study, and why you should lift weights when feeling stressed or depressed, can be scientifically explained as such:

Exercise and strength training, in both mice and people, increases the production within muscles of an enzyme called PGC-1alpha. In particular, exercise raises levels of a specific subtype of the enzyme known as PGC-1alpha1. 
Scientists identified a substance called kynurenine that accumulates in human and animal bloodstreams after stress. Kynurenine can pass the blood-brain barrier and has been shown to cause damaging inflammation in the brain, leading to depression.
In mice with high levels of PGC-1alpha1, the kynurenine produced by stress was set upon almost immediately by another protein expressed in response to signals from the PGC-1alpha1. This protein changed the kynurenine, breaking it into its component parts which could not pass the blood-brain barrier. In effect, the extra PGC-1alpha1 had called up guards that defused the threat to the animals’ brains and mood from frequent stress.
After muscle biopsies, scientists found that exercised muscle cells contained substantially more PGC-1alpha1, the substance that breaks down kynurenine.

Simply put, if you are stressed or depressed, go lift weights in order to kick in those enzymes that keep your kynurenine in check.
References:
http://well.blogs.nytimes.com/2014/10/01/how-exercise-may-protect-against-depression/

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Scientists in Stockholm help explain how exercise and strength training helps block ‘depression’ brain chemicals http://t.co/pAmROhUKG8

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Kavanaugh Accuser’s Classmate Backs Off Claims She Heard About Alleged Assault

“That it happened or not, I have no idea,” Cristina King Miranda told NPR’s Nina Totenberg. “I can’t say that it did or didn’t.”

The Duran

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Authored by Amber Athey via The Daily Caller:


A classmate of Dr. Christine Blasey Ford is backing off of claims that she knew anything about an alleged sexual assault committed by Supreme Court nominee Brett Kavanaugh.

Cristina King Miranda, who attended high school with Ford, wrote on Facebook this week that she heard school rumors about an incident involving Kavanaugh and Ford back in the 1980s. Miranda later deleted the post and said she did not want to talk to the media about her claims.

However, Miranda spoke to NPR on Thursday and clarified that she has no information about an alleged assault.

“That it happened or not, I have no idea,” Cristina King Miranda told NPR’s Nina Totenberg. “I can’t say that it did or didn’t.”

Miranda’s new statement directly contradicts her Facebook post, in which she wrote, “The incident DID happen, many of us heard about it in school.”

“In my post, I was empowered and I was sure it probably did [happen],” Miranda told NPR this morning. “I had no idea that I would now have to go to the specifics and defend it before 50 cable channels and have my face spread all over MSNBC news and Twitter.”

Miranda said the Senate Judiciary Committee reached out to her after her post but that she would not testify if asked.

Dr. Ford previously said she had not told anyone about the incident until a therapist meeting in 2012. Ford also said the incident happened during the summer, contradicting Miranda’s assertion that she heard rumors about it in school.

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Pat Buchanan: “The Late Hit” On Judge Kavanaugh

Wha exactly is professor Ford’s case against Judge Kavanaugh?

Patrick J. Buchanan

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Authored by Patrick Buchanan via Buchanan.org:


Upon the memory and truthfulness of Christine Blasey Ford hangs the Supreme Court nomination of Judge Brett Kavanaugh, his reputation and possibly his career on the nation’s second-highest court.

And much more. If Kavanaugh is voted down or forced to withdraw, the Republican Party and conservative movement could lose their last best hope for recapturing the high court for constitutionalism.

No new nominee could be vetted and approved in six weeks. And the November election could bring in a Democratic Senate, an insuperable obstacle to the elevation of a new strict constructionist like Kavanaugh.

The stakes are thus historic and huge.

And what is professor Ford’s case against Judge Kavanaugh?

When she was 15 in the summer of ’82, she went to a beer party with four boys in Montgomery County, Maryland, in a home where the parents were away.

She says she was dragged into a bedroom by Brett Kavanaugh, a 17-year-old at Georgetown Prep, who jumped her, groped her, tried to tear off her clothes and cupped her mouth with his hand to stop her screams.

Only when Kavanaugh’s friend Mark Judge, laughing “maniacally,” piled on and they all tumbled off the bed, did she escape and lock herself in a bathroom as the “stumbling drunks” went downstairs. She fled the house and told no one of the alleged rape attempt.

Not until 30 years later in 2012 did Ford, now a clinical psychologist in California, relate, in a couples therapy session with her husband, what happened. She says she named Kavanaugh as her assailant, but the therapist’s notes of the session make no mention of Kavanaugh.

During the assault, says Ford, she was traumatized. “I thought he might inadvertently kill me.”

Here the story grows vague. She does not remember who drove her to the party. She does not say how much she drank. She does not remember whose house it was. She does not recall who, if anyone, drove her home. She does not recall what day it was.

She did not tell her parents, Ford says, as she did not want them to know she had been drinking. She did not tell any friend or family member of this traumatic event that has so adversely affected her life.

Said Kavanaugh in response, “I categorically and unequivocally deny this allegation. I did not do this back in high school or at any time.”

Mark Judge says it never happened.

Given the seriousness of the charges, Ford must be heard out. But she also needs to be cross-examined and have her story and character probed as Kavanaugh’s has been by FBI investigators as an attorney for the Ken Starr impeachment investigation of Bill Clinton, a White House aide to George Bush, a U.S. appellate judge and a Supreme Court nominee.

During the many investigations of Kavanaugh’s background, nothing was unearthed to suggest something like this was in character.

Some 65 women who grew up in the Chevy Chase and Bethesda area and knew Kavanaugh in his high school days have come out and spoken highly of his treatment of girls and women.

Moreover, the way in which all of this arose, at five minutes to midnight in the long confirmation process, suggests that this is political hardball, if not dirt ball.

When Ford, a Democrat, sent a letter detailing her accusations against Kavanaugh to her California congresswoman, Anna Eshoo, Ford insisted that her name not be revealed as the accuser.

She seemingly sought to damage or destroy the judge’s career behind a cloak of anonymity. Eshoo sent the letter on to Sen. Diane Feinstein, who held it for two months.

Excising Ford’s name, Feinstein then sent it to the FBI, who sent it to the White House, who sent it on to the Senate to be included in the background material on the judge.

Thus, Ford’s explosive charge, along with her name, did not surface until this weekend.

What is being done here stinks. It is a transparently late hit, a kill shot to assassinate a nominee who, before the weekend, was all but certain to be confirmed and whose elevation to the Supreme Court is a result of victories in free elections by President Trump and the Republican Party.

Palpable here is the desperation of the left to derail Kavanaugh, lest his elevation to the high court imperil their agenda and the social revolution that the Warren Court and its progeny have been able to impose upon the nation.

If Kavanaugh is elevated, the judicial dictatorship of decades past, going back to the salad days of Earl Warren, William Brennan, Hugo Black and “Wild Bill” Douglas, will have reached its end. A new era will have begun.

That is what is at stake.

The Republican Senate should continue with its calendar to confirm Kavanaugh before Oct. 1, while giving Ford some way to be heard, and then Kavanaugh the right to refute. Then let the senators decide.

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Arizona Senator Jeff Flake Opposes Vote on Kavanaugh Until Leftist Accuser Has Her Say

The end of the Republic inches closer as Identity Politics knows no bounds: Republicans join the fight to delay Brett Kavanaugh confirmation vote.

Alex Christoforou

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Via The Gateway Pundit


FLAKE OUT — ARIZONA SENATOR OPPOSES VOTE ON KAVANAUGH

Anti-Trump Senator Jeff Flake, a member of the Senate Judiciary Committee, said in an interview Sunday evening that until he learns more about the sexual assault allegation regarding Brett Kavanaugh, he is “not comfortable voting yes” on Kavanaugh.

It’s Flakes last chance to poke President Trump and the country in the eye before he rides retires and likely finds a job in the liberal media.

Via Mike Cernovich:

Kavanaugh’s accuser is a far left anti-Trump activist.

Via Zerohedge


Over the past few days, what appeared at first to be a merely token resistance to the nomination of Trump SCOTUS pick Brett Kavanaugh has morphed into something entirely more menacing. And for the first time since Kavanaugh’s name was first floated in June, his nomination may be in jeopardy.

After allegations of decades-old sexual improprieties first surfaced last week, it looked as if Kavanaugh would easily surmount this obstacle. But we have to give the Democrats credit: They have lined up their dominoes perfectly. And on Sunday, they set their plan in motion when the Washington Post published an in-depth interview with Kavanaugh’s accuser, Christine Blasey Ford. The story detailed a blow-by-blow accounting of Ford’s allegations, as well as her explanation for why she neglected to share her experience until decades later. Tellingly, the story also noted that Democrats have been sitting on the story since July, and that Ford only decided to out herself after some unscrupulous members of the Judiciary Committee shared her identity with the press – or at least that’s what California Sen. Dianne Feinstein’s office alleges.

While the allegations are relatively tame by #MeToo era standards (the incident allegedly unfolded when Kavanaugh was 17), it has apparently been enough for Democrats and a handful of turncoat moderate Republicans to successfully shut down a planned Thursday vote of the Judiciary Committee. Arizona Sen. Jeff Flake effectively shut down the vote last night when he revealed that he wanted to hear more from Ford before voting. Without Flake, the Republicans’ 11-10 majority on the Judiciary Committee shifts to a 10-11 vote in favor of the Democrats. While Committee Chairman Charles Grassley has said he’d like the vote to proceed as scheduled, media reports say he is quietly working to organize a private call involving Ford and curious Senators in an effort to help mitigate their concerns.

But looking further ahead, Republican leaders might have more difficulty as Tennessee Republican Bob Corker – who is not a member of the Judiciary Committee but could still hold up the final confirmation vote – said Sunday that he’d also like to see Thursday’s committee vote delayed.

Here’s more from Bloomberg:

“I’ve made it clear that I’m not comfortable moving ahead with the vote on Thursday if we have not heard her side of the story or explored this further,” said Flake, who has the power to stall consideration if all Democrats on the panel join him since Republicans only hold an 11-10 majority on the committee. Flake’s office didn’t respond to requests for comment.

Corker of Tennessee, who isn’t a member of the panel but whose vote is critical to confirmation, also doesn’t want the committee to vote on Kavanaugh’s confirmation until Ford’s allegations can be heard, said his spokeswoman, Micah Johnson. The senator wants the allegations to be heard promptly, she said.

The backlash intensified late Sunday when Alaska Sen. Lisa Murkowski told CNN that Thursday’s hearing should be delayed.

“Well, I think that might be something they might have to consider, at least having that discussion,” Murkowski.

[…]

“This is not something that came up during the hearings. The hearings are now over. And if there is real substance to this it demands a response.”

However, at least one of the Senate’s reputed moderates has stood up to the Democrats in an interview with the New York Times, castigating them for withholding this information until so late in the process (remember: Feinstein justified this decision by saying she had referred Ford’s allegations to the FBI, who reportedly added them to his background check file).

“What is puzzling to me is the Democrats, by not bringing this out earlier, after having had this information for more than six weeks, have managed to cast a cloud of doubt on both the professor and the judge,” Collins told The New York Times.

Collins asked if Democrats believed Ford, “why didn’t they surface this information earlier,” and if they didn’t believe Ford, “why did they decide at the 11th hour to release it?”

“It is really not fair to either of them the way it is was handled,” Collins said.

Collins comments come after Ford spoke publicly about the alleged incident for the first time during an interview with The Washington Post that was published on Sunday.

On Monday, in the latest sign that Ford could appear at an embarrassing public hearing, Ford’s attorney, Debra Katz, told “Today” that her client would be willing to testify publicly before the Senate Judiciary Committee. “She’s a credible person. These are serious allegations. And they should be addressed.”

The White House, for its part, is standing by Kavanaugh, and allowing the Senate to sort things out. According to Bloomberg, Kellyanne Conway said Ford should not be “insulted and ignored” in what appears to be an attempt to beat the Democrats at their own virtue-signaling game.

Still, according to a White House spokesperson, Trump isn’t giving an inch. Washington Post reporter Seung Min Kim, citing WH spokesperson Kerri Kupec, reported that Judge Kavanaugh “categorically and unequivocally” denied this allegation: “This has not changed. Judge Kavanaugh and the White House both stand by that statement,”she said.

In fact, as Axios reports, Senate Republicans could “play hardball” by calling on Ford to testify before Thursday’s scheduled vote. Though Republicans wouldn’t surprised if Ford holds a press conference or gives a TV interview, which Axios says “would raise the stakes considerably.” Chuck Schumer, meanwhile, has repeatedly called for an FBI investigation and a postponement of the vote

To be sure, the Democrats’ goals here are obvious. After Sen. Corey Booker’s “selfless” decision to release unauthorized documents about Kavanaugh’s time in the Bush Administration failed to even delay the process, Democrats have now played their Trump card – no pun intended. Their goal: Delay Kavanaugh’s confirmation at least until the Oct. 1 mark – the beginning of SCOTUS’s next term – to put a halt to any controversial decisions that could reverse important precedents. Of course, their ultimate goal is to stonewall the White House until after Nov. 6, when a few victories in the midterms might allow them to sink Kavanaugh’s nomination once and for all.

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